What is XENICAL 120 mg?
Each capsule contains 120 mg active orlistat
84 capsules pack
Original ROCHE brand
XENICAL 120 mg. is an oral prescription weight loss medication used to help obese people lose weight and keep this weight off. XENICAL works in your intestines, where it blocks some of the fat you eat from being absorbed. This undigested fat is then eliminated in your bowel movements. XENICAL should be used together with a reduced-calorie diet that your doctor will recommend. Excess weight has been proven to contribute to an increased risk of developing many medical problems, including high blood pressure, high cholesterol, heart disease, and diabetes. The consumption of excess fatty food and calories plays a significant role in the development of excess weight. While fat is an important component of a balanced diet, the consumption of excess fat contributes to excess body weight, since fat provides twice the number of calories per gram of weight as carbohydrates and protein. Reduction of dietary fat intake is one potential way of losing weight. Before buy xenical you ned to know all about this drug.
How does XENICAL work?
If you eat an excess amount of fat or calories, the excess is stored as fat by the body resulting in weight gain. When you eat fat, your body breaks it down into its simplest components so that it can be absorbed. Enzymes in your intestinal tract, called lipases, help digest (or break down) fat. When you take XENICAL with meals, this drug attaches to the lipases and blocks them from breaking down some of the fat you have eaten. The undigested fat cannot be absorbed and is eliminated in your bowel movements. By working this way, XENICAL helps block about 30% of the fat eaten in food from being absorbed by your body.
Who should use XENICAL?
A weight loss program that includes a reduced-calorie diet and appropriate physical activity may be adequate in some patients. You should discuss with your doctor or other health care provider whether XENICAL 120 mg. should be added to such a program. This weight loss drug may be right for you if you are considerably overweight (at least 30% above ideal weight or a body mass index of 30 or greater). XENICAL 120 mg. may also be right for you if you are overweight (at least 20% above ideal weight or a body mass index of 27 or greater) and also have other risk factors such as high blood pressure, high cholesterol, heart disease, or diabetes. After you have determined that you are good for this drug you can buy xenical for your weight loss.
How to determine your body mass index (BMI):
The chart link below illustrates BMI according to a variety of weights and heights. The BMI is calculated by dividing your weight in kilograms by your height in meters squared. To use this chart: • Find the height closest to your height in the left-hand column. • Then move across the top row to find the weight closest to your weight. • The number where these two meet is your BMI. (For example, a person who weighs 180 lbs and is 5’5” would have a BMI of 30.) You need to know your BMI before buy xenical.
BMI index determine – see more
XENICAL is available for oral administration as a dark-blue or turquoise hard-gelatin capsule.
The dark blue capsule is imprinted with light blue and the turquoise capsule is imprinted with black.
Each capsule contains a pellet formulation consisting of:
1. 120 mg of orlistat
1. microcrystalline cellulose
2. sodium starch glycolate
3. sodium lauryl sulfate
The dark blue capsule shell contains gelatin:
titanium dioxide and FD&C Blue No. 1, with printing of pharmaceutical glaze NF, titanium dioxide, and FD&C Blue No. 1 aluminum lake. The turquoise capsule shell contains gelatin, titanium dioxide, and FD&C Blue No. 2 with black printing ink containing pharmaceutical grade shellac, dehydrated alcohol, isopropyl alcohol, butyl alcohol, propylene glycol, strong ammonium solution, potassium hydroxide and black iron oxide.
Drug-drug interaction studies indicate that XENICAL 120mg. had no effect on pharmacokinetics and/or pharmacodynamics of alcohol, digoxin, glyburide, nifedipine (extended-release tablets), oral contraceptives, phenytoin, pravastatin, or warfarin. Alcohol did not affect the pharmacodynamics of orlistat.
Pregnancy Category B. Teratogenicity studies were conducted in rats and rabbits at doses up to 800 mg/kg/day. Neither study showed embryotoxicity or teratogenicity. This dose is 23 and 47 times the daily human dose calculated on a body surface area (mg/m2 ) basis for rats and rabbits, 525 respectively. The incidence of dilated cerebral ventricles was increased in the mid- and high-dose groups of the rat teratology study. These doses were 6 and 23 times the daily human dose calculated on a body surface area (mg/m2 ) basis for the mid- and high-dose levels, respectively. This finding was not reproduced in two additional rat teratology studies at 530 similar doses. There are no adequate and well-controlled studies of XENICAL in pregnant women. Because animal reproductive studies are not always predictive of human response, XENICAL is not recommended for use during pregnancy.
It is not known if orlistat is secreted in human milk. Therefore, XENICAL 120 mg. should not be taken by nursing women.
The recommended dose of XENICAL is one 120-mg capsule three times a day with each main meal containing fat (during or up to 1 hour after the meal). The patient should be on a nutritionally balanced, reduced-calorie diet that contains approximately 30% of calories from fat. The daily intake of fat, carbohydrate, and protein should be distributed over three main meals. If a meal is occasionally missed or contains 631 no fat, the dose of this drug can be omitted.
Because XENICAL has been shown to reduce the absorption of some fat-soluble vitamins and beta-carotene, patients should be counseled to take a multivitamin containing fat-soluble vitamins to ensure adequate nutrition (see PRECAUTIONS: General). The supplement should be taken at least 2 hours before or after the administration of XENICAL, such as at bedtime. For patients receiving both orlistat and levothyroxine therapy, administer levothyroxine and orlistat at least 4 hours apart. Doses above 120 mg three times a day have not been shown to provide additional benefit. Based on fecal fat measurements, the effect of this diet pills is seen as soon as 24 to 48 hours after dosing. Upon discontinuation of therapy, fecal fat content usually returns to 642 pretreatment levels within 48 to 72 hours. The safety and effectiveness of XENICAL 120 mg. beyond 4 years have not been determined at this time.
Single doses of 800 mg XENICAL and multiple doses of up to 400 mg three times a day for 15 days have been studied in normal weight and obese subjects without significant adverse findings. Should a significant overdose of XENICAL occur, it is recommended that the patient be observed for 24 hours. Based on human and animal studies, systemic effects attributable to the lipase-inhibiting properties of orlistat should be rapidly reversible.
• consistently have problems absorbing food (chronic malabsorption); or
• have gallbladder problems; or
• are pregnant or are breastfeeding a child; or
• have ever had an allergic reaction to orlistat or any of the inactive ingredients in XENICAL.
Before beginning treatment with XENICAL 120 mg, make sure your doctor knows if you are:
• allergic to any medicines, foods, or dyes;
• taking any other weight-loss medication;
• taking cyclosporine;
• taking thyroid medicine;
• taking any other medicines (including those not prescribed by your doctor);
• taking any dietary supplements, including herbal products;
• planning to become pregnant; or
• anorexic or bulimic. This information will help you and your physician decide if the expected advantages of XENICAL are greater than any possible disadvantages.
The recommended dose is one 120 mg capsule by mouth with liquid at each main meal that contains fat. You can take XENICAL in conjunction with a mildly reduced-calorie diet up to 3 times a day. Each time you take XENICAL, your meal should contain no more than about 30% of calories from fat. Take XENICAL during meals or up to one hour after a meal. If you occasionally miss a meal or have a meal without fat, you can omit your dose of this drug. Doses greater than 120 mg three times a day have not been shown to provide an additional weight loss benefit.
You should use XENICAL 120 mg. together with a nutritionally balanced, mildly reduced-calorie diet that contains no more than about 30% of calories from fat. You should evenly divide your daily intake of fat, carbohydrates, and protein over 3 main meals.
You should try to follow a healthy eating plan such as the one developed by the American Heart Association. Following this eating plan will help you lose weight while decreasing some of the possible gastrointestinal effects you may experience while taking XENICAL.
If your daily calorie
The recommended daily
grams of fat (in a 30% fat
• XENICAL has been shown to reduce the absorption of certain vitamins. You should take a multivitamin containing vitamins D, E, K, and beta-carotene once a day at least 2 hours before or after the administration of XENICAL, such as at bedtime.
• Some patients taking XENICAL 120 mg. may develop an increased risk for the development of kidney stones. Promptly report any symptoms of back pain or blood in the urine.
• Some patients prescribed XENICAL may already be at increased risk for the formation of gall stones. Weight loss with XENICAL can increase the risk of gall stones. Promptly report any symptoms of pain in the upper right portion of the abdomen. The pain may be accompanied by nausea and vomiting.
• There have been rare reports of severe liver injury in patients taking XENICAL 120 mg. Promptly discontinue use this drug and contact your healthcare provider if you develop symptoms suggestive of liver impairment, such as loss of appetite, itching, yellowing of the skin, dark urine, light colored stools, or right upper quadrant pain.
Be sure to discuss with your doctor all medications (including herbal products) you are currently taking, including medicines you can get without a prescription (over-the counter), to determine if this drug can be taken in addition to these medications. If you are taking cyclosporine, XENICAL and cyclosporine should be taken at least 2 hours apart. If your cyclosporine levels are being measured, more frequent monitoring may be necessary. If you are taking levothyroxine, XENICAL and levothyroxine should be taken at least 4 hours apart.
The use of XENICAL 120 mg. for more than 4 years has not been studied. You and your doctor should discuss how long you should use XENICAL.
Because XENICAL 120 mg. works by blocking the absorption of dietary fat, it is likely that you will experience some changes in bowel habits. These generally occur during the first weeks of treatment; however, they may continue throughout your use of this diet pills. These changes may include oily spotting, gas with discharge, urgent need to go to the bathroom, oily or fatty stools, an oily discharge, increased number of bowel movements, and inability to control bowel movements. Due to the presence of undigested fat, the oil seen in a bowel movement may be clear or have a coloration such as orange or brown.
These bowel changes are a natural effect of blocking the fat from being absorbed and indicate that XENICAL is working. They generally occur early in treatment, particularly after meals containing higher amounts of fat than are recommended. These symptoms are often temporary and may lessen or disappear as you continue treatment and keep to your recommended diet of meals containing no more than about 30% fat. However, these side effects may occur in some individuals over a period of 6 months or longer.
In obese adolescent patients treated with XENICAL, the side effects reported were similar to those observed in adults.
If you are concerned about these or any other side effects you experience while taking XENICAL, talk to your doctor or pharmacist.
You must use XENICAL 120 mg. with a recommended mildly reduced-calorie diet. You should also follow a program of regular physical activity, such as walking. However, before you undertake any activity or exercise program, be sure to speak with your doctor or health care professional.
To help you get started on reducing the fat in your diet to around 30%, read the labels on all the foods you buy. You should avoid foods that contain more than 30% fat while you are taking XENICAL.
• When eating meat, poultry or fish, limit your portion to 2 or 3 ounces (roughly the size of a deck of cards). Choose lean cuts of meat and remove the skin from poultry. Fill up your meal plate by including more grains, fruits, and vegetables.
• Replace whole-milk products with nonfat or 1% milk and nonfat, reduced-fat, or low fat dairy items.
• Cook with less fat. Use vegetable oil spray when cooking. Salad dressings, many baked items, and prepackaged, processed, and fast foods are usually high in fat. Use the low- or non-fat versions and/or cut back on serving sizes.
• When dining out, ask how foods are prepared and request that they be prepared with little or no added fat.
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